Light Switches Brain Pathway On-and-Off to Dissect How Anxiety Works
Scientists, for the first time, have switched anxiety on-and-off in active animals by shining light at a brain pathway. Instinctively reclusive mice suddenly began exploring normally forbidding open spaces when a blue laser activated the pathway – and retreated into a protected area when it dimmed. By contrast, anxiety-like behaviors increased when an amber laser inhibited the same pathway.
Researchers, supported in part by NIMH, used a virus, genetic engineering and fiber-optics to control the pathway in the brain’s fear center with millisecond precision.
“Our findings reveal how balanced antagonistic brain pathways are continuously regulating anxiety,” explained Karl Deisseroth, M.D., Ph.D., of Stanford University, a practicing psychiatrist as well as a neuroscientist. “We have pinpointed an anxiety-quelling pathway and demonstrated a way to control it that may hold promise for new types of anti-anxiety treatments.”
NIMH grantees Deisseroth, Kay M. Tye, Ph.D., and colleagues, report on their findings March 17, 2011 in the journal Nature.


![The oldest surviving illustrated manuscript written in Arabic on any subject is a manuscript on paper of Abd al-Rahman al-Sufi’s Treatise on the Fixed Stars preserved in the Bodleian Library, Oxford [Ms. Marsh 144. p. 165].
“The pictures show the configurations of the stars in the forty-eight constellations recognized by Ptolemy, but the figures are dressed in Oriental rather than classical Greek garb. Al-Sufi wrote in his text that although he knew of another illustrated astronomical treatise, he copied his illsutrations directly from images engraved on a celestial globe, indicating that he was not working in a manuscript tradition.
According to the eleventh-century scholar al-Biruni, al-Sufi explained that he had laid a very thin piece of paper over a celestial globe and fitted it carefully over the surface of the sphere. He then traced the outlines of the constellations and the locations of individual stars on the paper. Al-Biruni later commented that this procedure ‘is an [adequate] approximation when the figures are small but it is far [from adequate] if they are large.’
The Oxford manuscript of al-Sufi’s text was copied from the author’s original by his son” (Bloom, Paper Before Print. The History and Impact of Paper in the Islamic World [2001] 143-44 and figure 51).](http://24.media.tumblr.com/tumblr_m4kkfaIcwq1qzjp8zo1_500.jpg)



